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Shadows Over Loathing Chemistry Guide – Chemical Combinations

Yeah, science!

I really love the RPG genre. You can have a huge and vast 3d land, and then you have a stick figure, black and white, filled with monsters and mysteries game that is overwhelmingly positive, according to Steam. Well, call me impressed. See developers? You just need to give people what they want and they will react positively. Who knew! Well, that should be the first class in game development 101. Anyway, one of the things you can do in game is to use chemistry to create new chemical compounds. Do not try this at home. Here is the Shadows Over Loathing chemistry guide and all chemical combinations.

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Shadows Over Loathing Chemistry Guide

Before you begin concocting your chemicals to destroy the world, you must understand how it works. You see, for each material in the game, there is an action or effect that modifies said material in order to create a specific combination. The materials are represented by the first two digits of a combination, while the action or effect is represented in the last two. Check out this table below to understand the Shadows Over Loathing chemistry guide, what each of the numbers mean, and then you will have the Chemical Combinations List attached for you to check out all possible combinations in the game.

MaterialAction
11xx = Bolognaxx11 = Bleach
12xx = Umbralinexx12 = Softener
13xx = Chalkxx13 = Deodorizing
14xx = Barnaclexx14 = Loosening
21xx = Vellumxx21 = Straightening
22xx = Asbestosxx22 = Purifying
23xx = Rubberxx23 = Polishing
24xx = Corduroyxx24 = Bending
31xx = Bronzexx31 = Strengthening
32xx = Glassxx32 = Revivifying
33xx = Smokexx33 = Removing
34xx = Sandwichxx34 = Annihilating
41xx = Chromexx41 = Insulting
42xx = Goldxx42 = Doubling
43xx = Leatherxx43 = Thickening
44xx = Hairxx44 = Dissolving

Chemical Combinations List

NameChemical Combination
Asbestos Bleaching Juice2211
Asbestos Deodorizing Juice2213
Asbestos Purifying Juice2222
Asbestos Straightening Juice2221
Asbestos Strengthening Juice2231
Bologna Purifying Juice1122
Bologna Softening Juice1112
Bronze Bleaching Juice3111
Bronze Deodorizing Juice3113
Bronze Polishing Juice3123
Bronze Purifying Juice3122
Bronze Removing Juice3133
Bronze Revivifying Juice3132
Bronze Softening Juice3112
Bronze Straightening Juice3121
Bronze Strengthening Juice3131
Chalk Bleaching Juice1311
Chalk Deodorizing Juice1313
Chalk Polishing Juice1323
Chalk Purifying Juice1322
Chalk Removing Juice1333
Chalk Revivifying Juice1332
Chalk Softening Juice1312
Chalk Straightening Juice1321
Chalk Strengthening Juice1331
Chrome Bleaching Juice4111
Chrome Polishing Juice4123
Glass Polishing Juice3223
Glass Revivifying Juice3232
Glass Softening Juice3212
Rubber Deodorizing Juice2313
Rubber Strengthening Juice2331
Smoke Bleaching Juice3311
Smoke Removing Juice3333
Smoke Revivifying Juice3332
Smoke Softening Juice3312
Smoke Straightening Juice3321
Smoke Strengthening Juice3331
Umbraline Removing Juice1233
Umbraline Softening Juice1212
Vellum Straightening Juice2121
Vellum Bleaching Juice2111
Vellum Deodorizing Juice2113
Vellum Polishing Juice2123
Vellum Removing Juice2133
Vellum Revivifying Juice2132
Vellum Softening Juice2112
Vellum Strengthening Juice2131

Related: Shadows Over Loathing – How to Solve Mudhenge Puzzle

Now that you know what your Chemical Combinations do, please, don’t do this in real life. Really, don’t even try. But hey, these could be useful in the game, so don’t be shy and continue experimenting with these combinations. In-game, that is. Anyway, good luck!


Shadows Over Loathing is available on Windows and macOS. Please check out Gamer Journalist on Facebook to join the discussion and keep up to date with our content. You might also like to check out or guides on 10 Best Video Games That Are Entirely in Black and White.

Author
Image of Alejandro Josan
Alejandro Josan
A musician with a heart of a gamer, Alejandro's life has always been accompanied by adventures on Nintendo platformers, countless hours of fantasy RPGs and several third-party FPSs. Currently, he is studying Game Design and Development, preparing for a long career in the video game industry.