How to Unlock Helminth Invigoration in Warframe

My deepest nightmare come true. But great buffs, though!

Warframe offers a lot of content and there are a couple of secrets you can use to make your Warframes quite more powerful and skillful. One of these secrets is quite a weird and probably nightmare inducing mechanic that resides in your Orbiter. Helminth is an infested hivemind that has the ability to boost your Warframe’s skills. You can level Helminth in order to get the most powerful boosts available. Furthermore, thanks to a recent update, Helminth has received the ability to give Invigoration to your Warframes. Here is how to unlock Helminth Invigoration in Warframe.

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How to Unlock Helminth Invigoration

Helminth Invigoration, added in the Sisters of Parvos update, makes the Helminth Segment system a lot more attractive for players to use. This hivemind infested mass will provide boosts to your Warframes’ abilities. Now, it will be able to grant a powerful buff once a week to three random Warframes. Eventually, after applying ten boosts or invigorations, you will be able to choose your next Warframe to be invigorated. Here is how to unlock Helminth Invigoration in Warframe.

Helminth Invigoration Requisites and Crafting

  • You will need to unlock the Helminth Invigoration system from Son, located in Necralist.
  • Just like previous Helminth systems and buffs, you will need some requisites in order to unlock it:
    • You must have the previous Helminth Segment built and installed. If you need to build it, you need the following requirements:
      • Rank 3: Associate with the Entrati.
      • Mastery Rank 8 minimum.
      • 15,000 standing to purchase the blueprint.
      • To craft the Helminth Segment you will need:
        • 50,000 credits.
        • 5 Purple Velocipod Tags.
        • 20 Adrenal Alloys.
        • 5 Saturated Muscle Masses.
        • 15 Ganglions.
    • Rank 5: Family with the Entrari is needed.
    • 30,000 Standing is needed to purchase the blueprint.
  • Once you have purchased the Helminth Invigoration Segment Blueprint, you will need to craft it. You will need the following materials:
    • 50,000 credits.
    • 5 Vizier Predasite Tags.
    • 20 Tempered Bapholites.
    • 10 Pustulent Cognitive Nodules
    • 15 Pustulites.
  • The Helminth Invigoration Segment blueprint will take 24 hours to be crafted, just like the previous Helminth Segment blueprint. After this, you will be able to use this system freely.

Related: How to Farm Polymer Bundles in Warframe

Be sure to make the best out of the Invigoration’s buffs. Don’t forget to visit it often, so you can use it more strategically once you have the ability to choose which Warframe will receive a boost, aka an invigoration. Happy invigoration and happy hiveminding!


Warframe is free-to-play and available now on PlayStation 5, PlayStation 4, Xbox One, Xbox Series X/S, Nintendo Switch and Windows. Please check out Gamer Journalist on Facebook to join the discussion and keep up to date with our content. You might also like to check out or guides on Warframe Tier List (December 2022) and How to Get Arcane Blessing in Warframe.

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Author
Alejandro Josan
A musician with a heart of a gamer, Alejandro's life has always been accompanied by adventures on Nintendo platformers, countless hours of fantasy RPGs and several third-party FPSs. Currently, he is studying Game Design and Development, preparing for a long career in the video game industry.