All Items in Binding of Isaac: Rebirth

Binding of Isaac: Rebirth comes with a plethora of items to stumble upon – both good and bad. Here are all 341 items in the game and their exact usages.

This guide is a work in progress to compile all of the passive/useable items in the game.

All Items in Binding of Isaac: Rebirth

1. <3 – +1 Health Up. Fully restores all red hearts.
2. ???’s Only Friend – Spawns a controllable familiar fly.
3. 1Up – Grants an extra life to the player.
4. 20/20 – The player now shoots two tears.
5. 3 Dollar Bill – Randomizes your tears for every room.
6. 9 Volt – Reduces charge times by one.
7. Abaddon – Gives you 6 black hearts and tears now have the possibility of inflicting fear. Damage Up, Speed Up, and Evil Up.
8. Abel – Spawns a familiar that mirrors the player’s movements and shoots in the opposite direction.
9. Anarchist Cookbook – Spawns 6 troll bombs randomly.
10. Anemic – Range Up and grants Isaac toxic blood.
11. Ankh – Isaac respawns as Blue Baby.
12. Anti-Gravity – Anti Gravity tears and Tears Up.
13. Aquarius – Leaves a trail of tears behind the player that deals damage to enemies.
14. Aries – Speed Up and grants the player to deal damage upon enemy contact.
15. Ball Of Bandages – Spawns an orbital that can evolve, granting a chance of charming enemies.
16. Ball of Tar – Leaves a trail of tar behind the player that slows enemies and projectiles. Tears can now possibly trigger slowing enemies and their projectiles down.
17. Battery – Usable items can now be overcharged.
18. BBF – Spawns a respawn-able familiar fly that explodes on contact with enemies.
19. Bean – Poison any nearby enemy.
20. Belt – Speed Up.
21. Best Bud – Spawns a fly orbital when the player takes damage.
22. Best Friend – Distracts enemies as a doll that explodes.
23. BFFS! – All of the player’s familiars become larger, giving them bigger damage radius.
24. Big Fan – Spawns an orbital that blocks shots and deals contact damage.
25. Bible – The player can now fly.
26. Black Bean – Causes the player to fart poison gas when they take damage.
27. Black Candle – Evil Up – grants curse immunity.
28. Black Lotus – Health Up.
29. Blank Card – Stacks the same effect as current card in hand.
30. Blood Bag – Health Up. Fully restores all red heart containers.
31. Blood Clot – Damage Up and Range Up.
32. Blood Of The Martyr – +1.0 Damage Up.
33. Bloody Lust – Damage Up for the rest of the floor when the player takes damage.
34. Blue Cap – Health Up, Tears Up, and Shot Speed Down.
35. Blue Map – Reveals the current and future locations of Secret Rooms and Super Secret Rooms.
36. Bob’s Brain – Spawns a familiar that launches in the direction you shoot at that explodes on contact with enemies.
37. Bob’s Curse – All bombs have a poisoning effect. Grants 5 bombs with poisoning effect.
38. Bobby-Bomb – Grants 5 bombs with homing effect.
39. Body – +3 Health Up.
40. Bogo Bombs – All bomb pick-ups contain 2 bombs.
41. Bomb Bag – Spawns a familiar that drops bomb pickups every few rooms.
42. Boom! – Grants 10 bombs.
43. Box – Grants a card, pill, and trinket.
44. Blood Rights – Revokes a single half-heart from the player to damage all enemies in a room.
45. Bob’s Rotten Head – Poisons and damages all foes it is thrown in the vicinity of.
46. Book Of Belial – Damage Up for the current room only.
47. Book Of Revelations – Adds 1 soul heart and increases the chances for the boss to be a horseman.
48. Book Of Secrets – Players obtain any of these three items: Treasure Map, Compass, or Blue Map.
49. Book Of Shadows – Grants invulnerability for 10 seconds.
50. Book Of Sin – Spawns a random pick-up.
51. Boomerang – Stuns and damages foes that it is thrown at.
52. Box Of Spiders – Spawns 2-4 friendly critters.
53. Breath Of Life – Immune to tear damage for a certain amount of time.
54. Butter Bean – Farts on nearby enemies and knocks them away from the player.
55. Breakfast – Health Up.
56. Brimstone – Beam attack in place of tears.
57. Broken Watch – Upon entering a new room, there is a chance all enemies will be sped up or slowed down.
58. Brother Bobby – Spawns a familiar that shoots 3.5 tear damage.
59. Bucket Of Lard – +2 Health Up and Speed Down.
60. Bum Friend – Spawns a familiar that collects nearby coins and potentially drop a random pick-up.
61. Butt Bombs – Grants 5 bombs that dazes enemies.
62. Caffeine Pill – Speed Up. Player Size Down. Gives the player a random pill.
63. Cain’s Other Eye – Spawns a bouncy, tear throwing familial.
64. Cancer – Grants 3 soul hearts.
65. Capricorn – All Stats Up and provides 1 key, 1 bomb, and 1 coin.
66. Cat-O-Nine-Tails – Damage Up and Shot Speed Up.
67. Celtic Cross – If the player takes damage, there is a chance they will be invulnerable.
68. Ceremonial Robes – Grants Sin Up and 3 black hearts.
69. Champion Belt – Damage Up.
70. Charm Of The Vampire – Heals half a red heart upon killing a few enemies.
71. Chemical Peel – Stacks damage up depending on tear amount.
72. Chocolate Milk – The player can now charge shots for more damage by holding down the fire button.
73. Common Cold – Tears have a random chance of being poisonous.
74. Compass – Reveals the majority of icons on the map.
75. Contract From Below – Doubles pick-up drops.
76. Cricket’s Body – Tears Up and Range Down.
77. Cricket’s Head – +0.5 Damage Up. Tears gain additional knockback effect.
78. Cube Of Meat – Spawns an orbital that damages enemies and blocks tears.
79. Cupid’s Arrow – The players’ Tears now come out of the target upon impact.
80. Cursed Eye – Tears are now chargeable.
81. Candle – Allows for laser type damaging – funnels into a single path.
82. Converter – 2 soul/black hearts in place of 1 red heart container.
83. Crack The Sky – Overhead attacks come down from above on enemies randomly.
84. Crystal Ball – Reveals the entire map and grants the player a random tarot card/soul heart.
85. D4 – Rerolls all items you currently have.
86. D6 – Rerolls any items into another item.
87. D10 – Rerolls all enemies in the room.
88. D20 – Rerolls all pick-ups in the room with another random pick-up.
89. D100 – Rerolls all items you currently own and any items/pick-ups in the room.
90. Dad’s Key – Opens all closed doors in the current room, with some exclusions.
91. Dead Sea Scrolls – Random usable item effect.
92. Deck Of Cards – Gives a random tarot card.
93. Doctor’s Remote – Allows for a missile usage.
94. Daddy Longlengs – Spawns a familiar.
95. Dark Bum – Spawns a familiar.
96. Dark Matter – Damage Up and Tears now can have the fear element.
97. Dead Bird – If the player takes damage, a familiar is spawned that attacks nearby enemies for the duration of the room.
98. Dead Cat – Get 8 extra lives for having only 1 Heart remain.
99. Dead Dove – Gives the player flight and spectral tears.
100. Dead Onion – Tears become piercing. Range Up and Shot Speed Down.
101. Death’s Touch – Damage Up and Tears Down. Tears are now able to penetrate enemies.
102. Demon Baby – Spawns a familiar.
103. Dessert – +1 Health Up
104. Dinner – +1 Health Up
105. Distant Admiration – Spawns a fly orbital that deals contact damage.
106. Dollar – Gives the player 99 coins.
107. Dr. Fetus – The player now shoots bombs from their eyes instead of tears.
108. Dry Baby – Spawns a familiar.
109. E Coli – Enemies become poop.
110. Epic Fetus – Tears now become controllable.
111. Eve’s Mascara – x2 Damage, Shot Speed Down, and Tears Down.
112. Experimental Treatment – Increases all stats by 1 and swaps them around.
113. Fanny Pack – When the player takes damage, there is a chance he will drop a pick-up item.
114. Fate – Grants the player flight and an eternal heart.
115. Fire Mind – Tears now set enemies on fire, damaging them over time.
116. Forever Alone – Spawns an orbital that deals contact damage.
117. Flush! – Enemies become poop.
118. Forget Me Now – Refreshes all existing elements of the current room.
119. Gamekid – Turns the player into pacman.
120. Guppy’s Head – Spawns several friendly flies.
121. Guppy’s Paw – Replaces 1 red heart container with 3 soul hearts.
122. Gemini – Spawns an orbital that is attached to the player.
123. Ghost Baby – Spawns a familiar that shoots spectral tears.
124. Gimpy – When the player takes damage, there is a chance a soul heart or black heart will drop.
125. Gnawed Leaf – Standing still for a second will turn the player into stone.
126. Goat Head – Grants the player a Devil Room or Angel Room to appear after each floor.
127. Godhead – Damage Up, Range Up, Tears Down, and Shot Speed Down.
128. Growth Hormones – Damage Up and Speed Up.
129. Guardian Angel – Spawns an orbital.
130. Guillotine – Damage Up and Tears Up.
131. Guppy’s Collar – 50% chance to respawn with half a red heart upon death.
132. Guppy’s Hair Ball – Spawns a familiar.
133. Guppy’s Tail – Greatly increases chance of finding chests.
134. Habit – When the player takes damage, your usable item is charged with 1 charge.
135. Halo, The – Health Up, Damage Up, Tears Up, Range Up, and Speed Up.
136. Halo Of Flies – Spawns 2 fly orbitals that block enemy shots.
137. Harlequin Baby – Spawns a familiar that shoots 2 tears in two diagonal directions.
138. Headless Baby – Spawns a familiar.
139. Hive Mind – All friendly blue flies and spiders become bigger and do more damage.
140. Holy Grail – Grants flight and Health Up.
141. Holy Mantle – Grants negation for one instance of damage for the current room.
142. Holy Water – Spawns a familiar.
143. Hot Bombs – Grants 5 bombs.
144. Humbling Bundle – All consumables now drop stacked (up to two).
145. Head Of Krampus – Shoot Brimstone in all directions.
146. Hourglass – Slows down all enemies and their attacks in the current room.
147. How To Jump – Player now able to jump, even dash.
148. Isaac’s Tears – Fires 8 tears in a circle around him.
149. IV Bag – Takes a red half-heart and spawns some coins.
150. Infamy – High chance of negating damage from the front of the player.
151. Infestation – If the player takes damage, ally flies will spawn.
152. Infestations 2 – 1-2 ally fiends spawn upon player death.
153. Inner Eye – Tears Down significantly. The player now shoots 3 tears.
154. IPECAC – Tears are replaced with poison tear-like bombs.
155. Iron Bar – Damage Up. Tears now have a chance to concuss enemies.
156. Isaac’s Heart – Spawns a familiar that follows behind the player.
157. Jesus Juice – Damage Up and Range Up.
158. Judas’ Shadow – When you die, you will respawn in the previous room with 2 black hearts and gain a Damage Up.
159. Juicy Sack – Possibility to spawn friendly critters upon clearing rooms.
160. Jar – Picks up hearts while at full health.
161. Kamikaze! – Causes the player to explode and lose 1 heart as a result and injures near-by enemies.
162. Key Piece 1 – Game progression key item, part 1.
163. Key Piece 2 – Game progression key item, part 2.
164. Ladder – Allows the player to walk across gaps in tiles.
165. Latch Key – Grants a soul heart and Luck Up. Spawns 2 keys.
166. Lazarus’ Rags – The player respawns after dying with 1 heart and the Anemic item.
167. Leech – Spawns a familiar that attacks enemies and heals the player.
168. Leo – The player can now destroy breakable objects by approaching it.
169. Libra – Grants 6 keys, 6 bombs, and 6 coins.
170. Lil’ Brimstone – Spawns a familiar with Brimstone firing.
171. Lil’ Haunt – Spawns a fear inducing familiar that follows the player and damages nearby enemies.
172. Little Baggy – Allows 2 pills to be held and spawns a pill as well as turning all tarot cards into pills.
173. Little C.H.A.D. – Spawns a familiar that drops half a red heart every two rooms.
174. Little Chubby – Spawns a familiar that charges forward and destroys whatever is in its path.
175. Little Gish – Spawns a familiar that shoots out black tears, slowing down enemy and projectiles.
176. Little Steve – Spawns a familiar that shoots out homing tears.
177. Loki’s Horns – The player has a chance to fire 3 more tears in cardinal directions when they shoot a tear.
178. Lord Of The Pit – Grants flight.
179. Lost Contact – Shot Speed Down and tears now block enemy attacks.
180. Lucky Foot – Grants a higher chance to win.
181. Ludovico Technique – Tears are replaced with a controllable large tear.
182. Lump Of Coal – Increase in size and damage.
183. Lunch – Health Up.
184. Lemon Mishap – Drops a damage point that injures enemies.
185. Magic Fingers – Damages all enemies in the room for a price of 1 coin.
186. Mom’s Bottle Of Pills – Gives a random pill.
187. Mom’s Bra – Freezes all enemies.
188. Mom’s Pad – Enemies are subject to fear – runs away from Isaac.
189. Monster Manual – Spawns a random familiar for the room.
190. Monstro’s Tooth – Monstro targets a random enemy in the room, dealing massive damage.
191. Mr. Boom – Drops a large bomb which explodes after several seconds.
192. My Little Unicorn – Speed Up and grants the player invulnerability.
193. Maggy’s Bow – Health Up. All future red hearts heal for double.
194. Magic 8 Ball – Shot Speed Up. Spawns a random tarot card.
195. Magic Mushroom – Health Up, Damage Up, Range Up, and Speed Up. Enlarges Isaac and fully restores all red heart containers.
196. Magic Scab – Health Up and Luck Up.
197. Magneto – All pick-up on the floor move toward the player.
198. Mark, The – Damage Up and Speed Up. Grants a soul heart.
199. Match Book – Grants 3 bombs and a black heart.
200. MEAT! – Damage Up and Health Up.

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