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All Items in Binding of Isaac: Rebirth

There's plenty to choose from

Lilia Hellal

Published: Mar 14, 2023 08:16 pm

Binding of Isaac: Rebirth comes with a plethora of items to stumble upon – both good and bad. Here are all 341 items in the game and their exact usages.

All Items in Binding of Isaac: Rebirth

<3 – +1 Health Up. Fully restores all red hearts.
???’s Only Friend – Spawns a controllable familiar fly.
1Up – Grants an extra life to the player.
20/20 – The player now shoots two tears.
3 Dollar Bill – Randomizes your tears for every room.
9 Volt – Reduces charge times by one.
Abaddon – Gives you 6 black hearts and tears now have the possibility of inflicting fear. Damage Up, Speed Up, and Evil Up.
Abel – Spawns a familiar that mirrors the player’s movements and shoots in the opposite direction.
Anarchist Cookbook – Spawns 6 troll bombs randomly.
Anemic – Range Up and grants Isaac toxic blood.

Ankh – Isaac respawns as Blue Baby.
Anti-Gravity – Anti Gravity tears and Tears Up.
Aquarius – Leaves a trail of tears behind the player that deals damage to enemies.
Aries – Speed Up and grants the player to deal damage upon enemy contact.
Ball Of Bandages – Spawns an orbital that can evolve, granting a chance of charming enemies.
Ball of Tar – Leaves a trail of tar behind the player that slows enemies and projectiles. Tears can now possibly trigger slowing enemies and their projectiles down.
Battery – Usable items can now be overcharged.
BBF – Spawns a respawn-able familiar fly that explodes on contact with enemies.
Bean – Poison any nearby enemy.
Belt – Speed Up.

Best Bud – Spawns a fly orbital when the player takes damage.
Best Friend – Distracts enemies as a doll that explodes.
BFFS! – All of the player’s familiars become larger, giving them bigger damage radius.
Big Fan – Spawns an orbital that blocks shots and deals contact damage.
Bible – The player can now fly.
Black Bean – Causes the player to fart poison gas when they take damage.
Black Candle – Evil Up – grants curse immunity.
Black Lotus – Health Up.
Blank Card – Stacks the same effect as current card in hand.
Blood Bag – Health Up. Fully restores all red heart containers.

Blood Clot – Damage Up and Range Up.
Blood Of The Martyr – +1.0 Damage Up.
Bloody Lust – Damage Up for the rest of the floor when the player takes damage.
Blue Cap – Health Up, Tears Up, and Shot Speed Down.
Blue Map – Reveals the current and future locations of Secret Rooms and Super Secret Rooms.
Bob’s Brain – Spawns a familiar that launches in the direction you shoot at that explodes on contact with enemies.
Bob’s Curse – All bombs have a poisoning effect. Grants 5 bombs with poisoning effect.
Bobby-Bomb – Grants 5 bombs with homing effect.
Body – +3 Health Up.
Bogo Bombs – All bomb pick-ups contain 2 bombs.

Bomb Bag – Spawns a familiar that drops bomb pickups every few rooms.
Boom! – Grants 10 bombs.
Box – Grants a card, pill, and trinket.
Blood Rights – Revokes a single half-heart from the player to damage all enemies in a room.
Bob’s Rotten Head – Poisons and damages all foes it is thrown in the vicinity of.
Book Of Belial – Damage Up for the current room only.
Book Of Revelations – Adds 1 soul heart and increases the chances for the boss to be a horseman.
Book Of Secrets – Players obtain any of these three items: Treasure Map, Compass, or Blue Map.
Book Of Shadows – Grants invulnerability for 10 seconds.
Book Of Sin – Spawns a random pick-up.

Boomerang – Stuns and damages foes that it is thrown at.
Box Of Spiders – Spawns 2-4 friendly critters.
Breath Of Life – Immune to tear damage for a certain amount of time.
Butter Bean – Farts on nearby enemies and knocks them away from the player.
Breakfast – Health Up.
Brimstone – Beam attack in place of tears.
Broken Watch – Upon entering a new room, there is a chance all enemies will be sped up or slowed down.
Brother Bobby – Spawns a familiar that shoots 3.5 tear damage.
Bucket Of Lard – +2 Health Up and Speed Down.
Bum Friend – Spawns a familiar that collects nearby coins and potentially drop a random pick-up.

Butt Bombs – Grants 5 bombs that dazes enemies.
Caffeine Pill – Speed Up. Player Size Down. Gives the player a random pill.
Cain’s Other Eye – Spawns a bouncy, tear throwing familial.
Cancer – Grants 3 soul hearts.
Capricorn – All Stats Up and provides 1 key, 1 bomb, and 1 coin.
Cat-O-Nine-Tails – Damage Up and Shot Speed Up.
Celtic Cross – If the player takes damage, there is a chance they will be invulnerable.
Ceremonial Robes – Grants Sin Up and 3 black hearts.
Champion Belt – Damage Up.
Charm Of The Vampire – Heals half a red heart upon killing a few enemies.

Chemical Peel – Stacks damage up depending on tear amount.
Chocolate Milk – The player can now charge shots for more damage by holding down the fire button.
Common Cold – Tears have a random chance of being poisonous.
Compass – Reveals the majority of icons on the map.
Contract From Below – Doubles pick-up drops.
Cricket’s Body – Tears Up and Range Down.
Cricket’s Head – +0.5 Damage Up. Tears gain additional knockback effect.
Cube Of Meat – Spawns an orbital that damages enemies and blocks tears.
Cupid’s Arrow – The players’ Tears now come out of the target upon impact.
Cursed Eye – Tears are now chargeable.

Candle – Allows for laser type damaging – funnels into a single path.
Converter – 2 soul/black hearts in place of 1 red heart container.
Crack The Sky – Overhead attacks come down from above on enemies randomly.
Crystal Ball – Reveals the entire map and grants the player a random tarot card/soul heart.
D4 – Rerolls all items you currently have.
D6 – Rerolls any items into another item.
D10 – Rerolls all enemies in the room.
D20 – Rerolls all pick-ups in the room with another random pick-up.
D100 – Rerolls all items you currently own and any items/pick-ups in the room.
Dad’s Key – Opens all closed doors in the current room, with some exclusions.

Dead Sea Scrolls – Random usable item effect.
Deck Of Cards – Gives a random tarot card.
Doctor’s Remote – Allows for a missile usage.
Daddy Longlengs – Spawns a familiar.
Dark Bum – Spawns a familiar.
Dark Matter – Damage Up and Tears now can have the fear element.
Dead Bird – If the player takes damage, a familiar is spawned that attacks nearby enemies for the duration of the room.
Dead Cat – Get 8 extra lives for having only 1 Heart remain.
Dead Dove – Gives the player flight and spectral tears.
Dead Onion – Tears become piercing. Range Up and Shot Speed Down.

Death’s Touch – Damage Up and Tears Down. Tears are now able to penetrate enemies.
Demon Baby – Spawns a familiar.
Dessert – +1 Health Up
Dinner – +1 Health Up
Distant Admiration – Spawns a fly orbital that deals contact damage.
Dollar – Gives the player 99 coins.
Dr. Fetus – The player now shoots bombs from their eyes instead of tears.
Dry Baby – Spawns a familiar.
E Coli – Enemies become poop.
Epic Fetus – Tears now become controllable.

Eve’s Mascara – x2 Damage, Shot Speed Down, and Tears Down.
Experimental Treatment – Increases all stats by 1 and swaps them around.
Fanny Pack – When the player takes damage, there is a chance he will drop a pick-up item.
Fate – Grants the player flight and an eternal heart.
Fire Mind – Tears now set enemies on fire, damaging them over time.
Forever Alone – Spawns an orbital that deals contact damage.
Flush! – Enemies become poop.
Forget Me Now – Refreshes all existing elements of the current room.
Gamekid – Turns the player into pacman.
Guppy’s Head – Spawns several friendly flies.

Guppy’s Paw – Replaces 1 red heart container with 3 soul hearts.
Gemini – Spawns an orbital that is attached to the player.
Ghost Baby – Spawns a familiar that shoots spectral tears.
Gimpy – When the player takes damage, there is a chance a soul heart or black heart will drop.
Gnawed Leaf – Standing still for a second will turn the player into stone.
Goat Head – Grants the player a Devil Room or Angel Room to appear after each floor.
Godhead – Damage Up, Range Up, Tears Down, and Shot Speed Down.
Growth Hormones – Damage Up and Speed Up.
Guardian Angel – Spawns an orbital.
Guillotine – Damage Up and Tears Up.

Guppy’s Collar – 50% chance to respawn with half a red heart upon death.
Guppy’s Hair Ball – Spawns a familiar.
Guppy’s Tail – Greatly increases chance of finding chests.
Habit – When the player takes damage, your usable item is charged with 1 charge.
Halo, The – Health Up, Damage Up, Tears Up, Range Up, and Speed Up.
Halo Of Flies – Spawns 2 fly orbitals that block enemy shots.
Harlequin Baby – Spawns a familiar that shoots 2 tears in two diagonal directions.
Headless Baby – Spawns a familiar.
Hive Mind – All friendly blue flies and spiders become bigger and do more damage.
Holy Grail – Grants flight and Health Up.

Holy Mantle – Grants negation for one instance of damage for the current room.
Holy Water – Spawns a familiar.
Hot Bombs – Grants 5 bombs.
Humbling Bundle – All consumables now drop stacked (up to two).
Head Of Krampus – Shoot Brimstone in all directions.
Hourglass – Slows down all enemies and their attacks in the current room.
How To Jump – Player now able to jump, even dash.
Isaac’s Tears – Fires 8 tears in a circle around him.
IV Bag – Takes a red half-heart and spawns some coins.
Infamy – High chance of negating damage from the front of the player.

Infestation – If the player takes damage, ally flies will spawn.
Infestations 2 – 1-2 ally fiends spawn upon player death.
Inner Eye – Tears Down significantly. The player now shoots 3 tears.
IPECAC – Tears are replaced with poison tear-like bombs.
Iron Bar – Damage Up. Tears now have a chance to concuss enemies.
Isaac’s Heart – Spawns a familiar that follows behind the player.
Jesus Juice – Damage Up and Range Up.
Judas’ Shadow – When you die, you will respawn in the previous room with 2 black hearts and gain a Damage Up.
Juicy Sack – Possibility to spawn friendly critters upon clearing rooms.
Jar – Picks up hearts while at full health.

Kamikaze! – Causes the player to explode and lose 1 heart as a result and injures near-by enemies.
Key Piece 1 – Game progression key item, part 1.
Key Piece 2 – Game progression key item, part 2.
Ladder – Allows the player to walk across gaps in tiles.
Latch Key – Grants a soul heart and Luck Up. Spawns 2 keys.
Lazarus’ Rags – The player respawns after dying with 1 heart and the Anemic item.
Leech – Spawns a familiar that attacks enemies and heals the player.
Leo – The player can now destroy breakable objects by approaching it.
Libra – Grants 6 keys, 6 bombs, and 6 coins.
Lil’ Brimstone – Spawns a familiar with Brimstone firing.

Lil’ Haunt – Spawns a fear inducing familiar that follows the player and damages nearby enemies.
Little Baggy – Allows 2 pills to be held and spawns a pill as well as turning all tarot cards into pills.
Little C.H.A.D. – Spawns a familiar that drops half a red heart every two rooms.
Little Chubby – Spawns a familiar that charges forward and destroys whatever is in its path.
Little Gish – Spawns a familiar that shoots out black tears, slowing down enemy and projectiles.
Little Steve – Spawns a familiar that shoots out homing tears.
Loki’s Horns – The player has a chance to fire 3 more tears in cardinal directions when they shoot a tear.
Lord Of The Pit – Grants flight.
Lost Contact – Shot Speed Down and tears now block enemy attacks.
Lucky Foot – Grants a higher chance to win.

Ludovico Technique – Tears are replaced with a controllable large tear.
Lump Of Coal – Increase in size and damage.
Lunch – Health Up.
Lemon Mishap – Drops a damage point that injures enemies.
Magic Fingers – Damages all enemies in the room for a price of 1 coin.
Mom’s Bottle Of Pills – Gives a random pill.
Mom’s Bra – Freezes all enemies.
Mom’s Pad – Enemies are subject to fear – runs away from Isaac.
Monster Manual – Spawns a random familiar for the room.
Monstro’s Tooth – Monstro targets a random enemy in the room, dealing massive damage.

Mr. Boom – Drops a large bomb which explodes after several seconds.
My Little Unicorn – Speed Up and grants the player invulnerability.
Maggy’s Bow – Health Up. All future red hearts heal for double.
Magic 8 Ball – Shot Speed Up. Spawns a random tarot card.
Magic Mushroom – Health Up, Damage Up, Range Up, and Speed Up. Enlarges Isaac and fully restores all red heart containers.
Magic Scab – Health Up and Luck Up.
Magneto – All pick-up on the floor move toward the player.
Mark, The – Damage Up and Speed Up. Grants a soul heart.
Match Book – Grants 3 bombs and a black heart.
MEAT! – Damage Up and Health Up.

This list is a work-in-progress but we hope it proves helpful to you. Join in on the discussion and stay up to date with our content over at Gamer Journalist on Facebook. Interested in seeing more coverage on content such as this one? Then check out our articles of How to Get Liberty Cap in Binding of Isaac: Rebirth or How to Play Co-op in The Binding of Isaac: Repentance.

Author

Lilia Hellal

Fan of everything and anything dating sim and mystery related. Passion for gaming was kickstarted by Luminous Arc on the Nintendo DS and has since become obsessed with Fire Emblem, Rune Factory, Story of Seasons, Danganronpa and Zero Escape. Won't shut up about visual novels, JRPGs and otomes in general.